منابع مشابه
Langerhans Cells in Skin Lesions of Leprosy
Background: Langerhans cells are important in the pathogenesis of leprosy. A recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. Objective: To investigate a possible relationship between the number of Langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. Methods: An immunohistochemical staining for S100 prot...
متن کامل[Langerhans cell and HIV].
Heterosexual transmission of HIV is the most common mode of infection in the global HIV epidemic. In the absence of an effective vaccine, there is an urgent need for additional strategies to prevent new HIV infections. Evidence from a variety of investigations, including epidemiologic studies on sexual transmission, in vivo studies in rhesus monkey, and ex vivo studies using human explant model...
متن کاملHerpes simplex virus enhances HIV-1 transmission by Langerhans cells
Genital herpes is a risk factor to acquire HIV-1 infection by sexual contact, by increasing both infectivity of an infected person and susceptibility to acquire HIV-1. Here we have investigated the mechanisms that underlie the increased susceptibility to HIV-1 when people have genital herpes. Under steady state conditions, LCs capture HIV-1 through interaction with the C-type lectin Langerin, r...
متن کاملLangerhans cells in periodontal disease of HIV- and HIV+ patients undergoing highly active antiretroviral therapy.
The aim of this study was to assess and compare quantitatively the presence of S100+ Langerhans cells (LC) by immunochemistry techniques in HIV+ and HIV- gingivitis and periodontitis subjects. Additionally, it aimed to evaluate the correlation among densities of these cells with CD4+ and CD8+ T cells, and viral load levels in HIV+ subjects, all using Highly Active Antiretroviral Therapy (HAART)...
متن کاملVaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells.
Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4+ T cells without being productively infected themselves, and we point to a pathway that might enable HI...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1771rr5